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This indicates that Wnt7a is not required for correct bundle orientation and suggests that other Wnt members may compensate for Wnt7a or independently mediate the Wnt/PCP pathway in the developing cochlea (Dabdoub et al., Wnt5a , which is expressed in the Kölliker’s organ medial to the organ of Corti (Qian et al., 2007)

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Concentration-Response Research Principles Concentration-response studies examine whether copper-binding, signaling, gene-expression, matrix, or cellular endpoints change across predefined laboratory conditions