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In addition, this study also demonstrated that the inhibition of brain catalase, the enzyme responsible for alcohol oxidation into acetaldehyde, prevents both the formation of salsolinol in the pVTA and the increase of DA transmission in the AcbSh [41]

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The trial also showed that the combination produced dose-dependent, sustained weight loss without concerning additional adverse effects — the side effect profile was broadly consistent with what would be expected from each individual agent