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However, due to the lack of a placebo control and inherent biases of unblinded designs, these findings remain preliminary and insufficient to support clinical use (168)

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Therefore, the relatively low abundance of lipoylation in untreated cells suggests that lipoylation is rate-limiting for the OGDHc, and our findings are consistent with the accumulation of Lp glu following ABHD11 inhibition, which reduces OGDHc activity (Fig