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For Dioxane-water system, the polynomial has following values: W cal = 21.70104+10.372731 δ 1 -0.401841 δ 1 2 +0.032507δ 1 3 -0.000435δ 1 4 , (n=11, R 2 = 0.9999) -- (6) These polynomials are used successfully for the calculation of W, at any value of solubility parameter (δ 1 ), which was subsequently employed to calculate mole fraction solubility of solute in a solvent blend using backward regression

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The higher dose in the second half of the cycle is designed to reinforce the collagen synthesis, sirtuin activation, and anti-inflammatory pathways initiated in Phase 1

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