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However, up to 10% undergoes bioactivation to N -acetyl p -benzoquinone imine (NAPQI), a highly reactive electrophile, which is known to covalently bind to nucleophilic centers, including cysteine thiols in liver proteins (see Figure 1) (Jollow et al., 2015)

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also showed the same trend in knee symptoms and daily activity progression using the mean KOOS score in ten participants with degenerative meniscus tears without osteoarthritis according to Stoller classification after 3 months and 6 months of follow up (i.e., KOOS: 56.6 ± 15.7 baseline, 70.2 ± 16.8 post- 3 months, 72.7 ± 18.5 post- 6 months, p = 0.0007)