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Since B lymphocytes are secretory cells highly dependent on ER function, TMAO’s regulation of UPR may impact B cell development, differentiation, or antibody production ( In summary, despite limited direct evidence on TMAO’s impact on B lymphocytes, its ability to regulate pathways like UPR and NF-κB, which are essential for B cell function, suggests potential indirect effects

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GST inhibitors have been developed to target specific isoforms of these enzymes for disease treatment