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Therefore, it is not surprising that the GSH system has attracted the attention of pharmacologists as a possible target for medical intervention against cancer progression and chemoresistance

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In some embodiments, a concentration of the otoprotectant is at least or about 0.001 μM, 0.005 μM, 0.01 μM, 0.05 μM, 0.10 μM, 0.5 μM, 1 μM, 5 μM, 10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM, 70 μM, 80 μM, 90 μM, 100 μM, 120 μM, 140 μM, 160 μM, 180 μM, 200 μM, or more than 200 μM