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[52] developed a thymectomized adult mice model immunized with CII for 4 weeks in order to tolerate the T cells and found the occurrence of arthritis, which could be due to IFN-γ production by partially tolerant T cells with the help of B-cell though the existence of peripheral tolerance against the glycosylated CII 256–270 epitope

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Reported effects on texture and firmness derive from upregulated extracellular matrix production, improved barrier protein expression, and increased fibroblast activity