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These include: Over the Counter (OTC) pain medications, such as acetaminophen and ibuprofen help to relieve pain caused by fibroids Iron supplements are used to prevent or manage anemia caused by excessive bleeding Birth Control methods, such as contraceptive pills, intravaginal conception, injections, and intrauterine devices (IUDs), can be used to manage symptoms of fibroids and decrease heavy bleeding Gonadotropin-releasing hormone (GnRH) agonists can be used to temporarily shrink fibroids and help relieve symptoms With the exception of GnRH agonists, most medications do not directly affect the fibroid itself