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Studies have examined the dose-response relationships for MC1R-mediated melanogenesis with MT-II , comparing potency with MT-1 and native α-MSH to establish the structure-activity contribution of cyclisation to MC1R agonist potency , and have characterised the kinetics of tyrosinase upregulation, melanosome distribution, and melanin transfer to keratinocytes downstream of MT-II-induced MC1R activation