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The cGMP inhibits colonic noniceptors and acts as a second messenger in the downstream facilitation of intestinal fluid secretion ( Serum-Derived Bovine Immunoglobulins Serum-derived bovine immunoglobulin (SBI), marketed under the brand name EnteraGam ® , has been approved by the US Food and Drug Administration for use in patients with chronic loose and frequent stools including IBS-D and IBD under physician supervision ( Burkholderiales and Firmicutes Catonella in the duodenum brushings but not in the stools

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