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In 1921, insulin was the first peptide to be synthesised in a laboratory, but public interest in their therapeutic use waned until 2017, when semaglutide, better known as Ozempic, was approved by the United States Food and Drug Administration

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It also lowers the production of vital immune effectors by T cells and monocytes, enhances the number of myeloid-derived suppressor cells (MDSCs), and inhibits the cytotoxic functions of NK and NKT cells (104)