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Among them, GPX4 is a membrane-associated phospholipid hydroperoxidase, and it is also the only enzyme in the GPX family that directly reduces and destroys lipid hydroperoxides, which can reduce complex lipid compounds in addition to reducing H 2 O 2 and small molecule hydroperoxides

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Improved running wheel activity and early signs of fur restoration were the earliest measurable endpoints (Baar et al., 2017)