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5) have been identified: (1) ionotropic glutamate receptors, which directly gate ion channels, and (2) metabotropic glutamate receptors, which may be coupled to an ion channel or other cellular functions via an intracellular second messenger cascade

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Whereas Xpd TTD/TTD mice generally show less exploratory behavior compared to wildtype littermates, FOXO4-DRI treated animals were noticeably more active (Fig