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mean age 58.0 ± 9.7 years) found that Semax at 6,000 mcg/day intranasally — delivered as two 10-day courses separated by a 20-day interval — increased measurable plasma BDNF alongside improvements on the Barthel index and MRC motor scale over a ~5-month observation period, though effect sizes, confidence intervals, and p-values were not reported in the published abstract and the absence of randomization and placebo control limits causal inference

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and Peptostreptococcus ) strongly links to behavioral defects and the rise in pro-inflammatory cytokines in the CNS (Wlodarska et al., 2017