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Glutathione and the γ-glutamyl cycle The synthesis, transport and catabolism of GSH occur in a series of enzymatic steps and transports of membrane that are collectively called γ -glutamyl cycle (Figure 5) (74, 75)

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Intravenous Administration Direct intravenous injection would achieve 100% bioavailability and immediate peak concentrations, dramatically increasing the risk of severe cardiovascular side effects