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For this reason, the homeostasis of extracellular glutamate is tightly controlled by the combined activity of neuronal and glial membrane transporters, such as glutamate transporter-1 (GLT1), glutamate aspartate transporter (GLAST), and the cysteine/glutamate antiporter, or system xc – (Sxc – ), present in astrocytes, and EAAT3 present in neurons