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Moreover, it has been noted that exposure of cells to H 2 O 2 induces the increased expression of both the cystine xCT transporter (Lewerenz et al., 2013) and CSE (Wang et al., 2012), compatible with the idea that increased persulfide generation from Cys and/or Cys2 is a physiologically relevant oxidative stress response (Millikin et al., 2016)