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It was established that Epitalon promotes signal transducer and activator of transcription 1 (STAT1) phosphorylation, potentially through a receptor-independent mechanism that does not include interactions between IFN-α and IFN-R, as seen by the lack of effect on IFN-α production

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In 1973, researcher Loren Pickart isolated a tripeptide from human plasma that appeared to make aged liver tissue behave like younger tissue