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What causes schizophrenia based on current research There is an outstanding look at common questions for schizophrenia (including early warning signs) here: As you scroll down, take a look at the role of certain stressors during critical periods of brain development: Prenatal exposure to a viral infection Low oxygen levels during birth (from prolonged labor or premature birth) Exposure to a virus during infancy Early parental loss or separation Physical or sexual abuse in childhood They center around infection, stress, and trauma