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In another double-blind, placebo-controlled trial, an improvement in cognitive performance (i.e., MMSE score) was reported in AD patients randomized to receive 800 IU/day of all - rac -α-tocopherol (360 mg/day of RRR -α-tocopherol) for six months only when the treatment effectively reduced oxidative stress (as assessed by the measure of total glutathione and markers of lipid peroxidation in the blood) (110)