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LF, especially in its iron-saturated form, shows high resistance to proteolytic enzymes in the stomach, pancreas, and small intestine [15]

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Polyphenols can inhibit AP-1 activity by (i) blocking the binding of AP-1 to DNA, (ii) inactivating the AP-1 proteins, and (iii) interfering with the signal transduction pathways that activate AP-1 [207]