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Indeed, Serotonin Synthesis Amplification has been pursued since the 1970s, using as the active compound either 5-hydroxytryptophan, 5 HTP (the natural rate-limiting serotonin precursor) (11) , tryptophan (5-HTP precursor) (28) , methyl-folate (amplifies 5-HTP synthesis) (29) , lithium (amplifies 5-HTP synthesis) (34) , or thyroid hormone (amplifies 5-HTP synthesis) (35)