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Initially, human testes samples were procured from young donor patients and aged prostate cancer patients

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Canfosfamide (TLK 286, TELCYTA) is a glutathione analogue prodrug that is preferentially activated by GSTP1-1 into a vinyl sulfone derivative of the GSH backbone and an alkylating metabolite phosphorodiamidate that spontaneously forms aziridinium ring structures [108,109,110]