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15,36,37 Conversely Our data indicated that pretreatment with DUL followed by DOX improves renal function, evidenced by significantly lower serum levels of BUN and creatinine in the DUL + DOX group compared to the DOX control group, so this finding is accordance with the findings of previous studies about the nephroprotective properties of DUL in diabetic chronic kidney disease rat models, showed noticeable maintenance of renal functions