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To identify any changes in hydrophobic interactions, an intermolecular contact analysis at the protein-peptide interface was performed on all residues within 4 Å for FAT-1907 and FAT-LD2 (Supplementary Tables 3, 4)

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Activation of JNK then initiates a cascading effect, with translocation of phosphorylated JNK to the mitochondrial outer membrane58, where it binds with the Sab protein and initiates an Src-mediated inhibition of the electron transport and increases ROS production to amplify mitochondrial dysfunction61 and peroxynitrite formation59